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Healthcare online Keeping you up-to-date
VOL.  23     ISSUE:  7    July 2025 Medical Services Department

SQUARE Pharmaceuticals PLC.

Features

EDITORIAL TEAM

A S M Shawkat Ali

MBBS, M. Phil,

Rezaul Hasan Khan

MBBS, MPH

Rubyeat Adnan

MBBS, MPH

Moshfiqur Rahman

MBBS

Sm Fuad Hasan

MBBS

EDITORIAL

Dear Doctor:

Welcome to our healthcare bulletin 'e-SQUARE' !

Our current issue focused on some interesting features like

"Tirzepatide & Breast Cancer !", "Estrogen Effect !", "Sleep Apnea !", "Alzheimer’s Risk !", "Preeclampsia !", "Bipolar Disorder !".

In our regular feature, we have some products information of SQUARE Pharmaceuticals PLC. as well.

We always appratiate your feedback !

Click on to reply mode.

Yours sincerely,

 

Editorial Team

Reply Mode      : e-square@squaregroup.com

The views expressed in this publication do not necessarily reflect those of its editor or SQUARE PHARMACEUTICALS PLC.

Tirzepatide & Breast Cancer !

Weight-loss drug Tirzepatide shrinks breast cancer tumors

A recent study presented at ENDO 2025, the Endocrine Society's annual meeting, suggests that the anti-obesity drug Tirzepatide for obesity may reduce the growth of obesity-associated breast cancer. Conducted by researchers at the University of Michigan, the preclinical study found that tirzepatide significantly reduced both body fat and breast tumor size in a mouse model. Obesity is a known risk factor for worse breast cancer outcomes. While weight loss is associated with better prognosis, conventional methods are often difficult to maintain. Tirzepatide is a newer drug that targets both GLP-1 and GIP receptors, which are involved in appetite and metabolism regulation, making it a promising agent for significant weight reduction. In the study, 16 mice fed a high-fat diet to induce obesity were treated with tirzepatide or a placebo over a 16-week period. The tirzepatide-treated group experienced a 20% reduction in body weight, mostly due to loss of fat mass. Importantly, these mice also showed a significant decrease in breast tumor volume compared to the control group. Researchers found a strong correlation between tumor size and overall body weight, adipose tissue mass, and liver fat content. These findings indicate that tirzepatide’s anti-tumor effects may be linked to its ability to reduce fat mass, which in turn influences cancer growth. Though the results are preliminary and based on animal models, the study opens new avenues for considering anti-obesity medications as part of breast cancer risk management or treatment in obese individuals. Further research is ongoing in collaboration with the University of North Carolina to determine whether tirzepatide’s anti-cancer effects are due to weight loss alone or if it also has direct tumor-suppressive properties.

SOURCE: The Daily Science, July 2025

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 Estrogen Effect !

Oral Hormone Therapy Shows Long-Term Cardiovascular Benefits in Menopausal Women

A recent analysis from the Women’s Health Initiative reveals that estrogen-based oral hormone therapy may offer significant long-term benefits for cardiovascular health in postmenopausal women. The study, published in Obstetrics & Gynecology and led by Dr. Erin D. Michos and Dr. Jessica Nudy, examined six years of biomarker data from 2,696 women, part of a larger WHI clinical trial. Researchers found that hormone therapy, including both estrogen-only and estrogen-plus-progesterone treatments, led to favorable changes in cardiovascular biomarkers. Notably, LDL cholesterol decreased by 11%, total cholesterol and insulin resistance improved, and HDL cholesterol, the "good" cholesterol, by 13% in the estrogen-only group and 7% in the combined therapy group. Most striking was a reduction in lipoprotein a genetic cholesterol marker linked to increased heart attack and stroke risk by 15% and 20% in the respective groups. Lipoprotein(a) is largely unaffected by lifestyle changes and currently lacks FDA-approved therapies to reduce its levels, making this finding particularly impactful. The reduction was even more pronounced among American and Asian participants. However, the study also found an increase in triglycerides and coagulation factors, possibly due to liver metabolism during oral estrogen absorption, which may raise inflammatory markers. According to scientists, hormone therapy appears safe and potentially beneficial for healthy women within 10 years of menopause onset. These findings challenge previous concerns about cardiovascular risks and suggest hormone therapy could be a strategic option for improving heart health in select menopausal women. The study provides new insights into hormone therapy’s role beyond symptom relief, offering a promising avenue for cardiovascular risk management.

SOURCE: The Daily Science, July 2025

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Sleep Apnea !

 Sleep Apnea Linked to Memory and Thinking Problems

A new study suggests that people with symptoms of sleep apnea may be more likely to experience memory or thinking issues, adding to the growing awareness of how sleep quality affects brain health. While the study doesn't prove that sleep apnea causes cognitive decline, it highlights a significant association that deserves further attention.
Sleep apnea is a common but often underdiagnosed disorder where breathing repeatedly stops and starts during sleep. Symptoms include snorting, gasping, and breathing pauses, often accompanied by morning headaches, fatigue, and trouble focusing. These repeated disruptions in breathing can lower oxygen levels in the blood, which may affect brain function over time. Researchers at Boston Medical Center analyzed data from over 4,200 adults who completed surveys on their sleep patterns and cognitive function. Among the participants, 1,079 reported symptoms of sleep apnea. Of these, 33% also reported having memory or thinking problems compared to just 20% of those without sleep apnea symptoms. After adjusting for factors such as age, gender, race, and education, the researchers found that individuals with sleep apnea symptoms were 50% more likely to report cognitive issues. Although the study relies on self-reported data and further research is needed to establish a direct cause-and-effect relationship, it sends a clear message: poor sleep may be a warning sign of deeper health concerns. Regular screening for sleep apnea, especially for those with cognitive complaints, could be a crucial step toward preserving long-term brain health.

SOURCE: Science Daily News, July, 2025

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Alzheimer’s Risk !

Iron Buildup in Brain May Explain Early Alzheimer’s

The scientists studied brain tissue from people who had Alzheimer’s, Down syndrome with Alzheimer’s (DSAD), and people with neither condition. They found that people with DSAD had twice as much iron in a key brain area (prefrontal cortex) compared to others. This iron may come from tiny blood leaks in the brain.
Too much iron can trigger a harmful process called ferroptosis, where iron causes cell membranes to break down. This leads to oxidative damage, which is a kind of chemical stress that harms brain cells. In the study, DSAD brains had more of this damage and weaker defense systems to stop it. One part of brain cells called lipid rafts was especially affected. These rafts help with communication in the brain and also help make a protein called amyloid-beta (Aβ), which forms plaques in Alzheimer’s. The study found that in DSAD brains, lipid rafts had more damage, less protection, and more Aβ production.
The cause of this may be the extra copy of chromosome 21 in people with Down syndrome. This chromosome carries the gene for APP, a protein linked to Aβ plaques. More APP may lead to more iron buildup and more brain damage. The researchers hope that in the future, iron-removing drugs or antioxidants may help slow down Alzheimer’s in people with Down syndrome.

SOURCE: Science Daily News, July 2025

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Preeclampsia !

Lipid Profile May Help Detect Preeclampsia Early

Preeclampsia is a serious condition that can happen during pregnancy. It affects up to 7 out of every 100 pregnant women. It usually starts after 20 weeks and causes high blood pressure, kidney problems, and trouble with blood clotting. If not treated, it can lead to seizures, organ failure, and even death. Each year, about 70,000 women around the world die because of preeclampsia. Right now, doctors give low-dose aspirin to women who might be at risk, but it only works for about half of them. Also, aspirin needs to be started before 16 weeks of pregnancy, before symptoms appear. That’s why it’s very important to find a way to know who is at risk early in pregnancy. A new study led by a Scientist may offer a solution. His team studied blood samples from 57 pregnant women in the first 24 weeks of pregnancy. Later, some of these women developed preeclampsia, and some did not. The scientists looked at special types of fat in the blood, called lipids. They found that women who developed preeclampsia had a different pattern of lipids compared to those who stayed healthy. This pattern is called a lipid signature. This discovery could help doctors create a simple blood test in the future. Such a test would allow them to spot at-risk women early in pregnancy and start monitoring or treatment right away. This could prevent many serious problems and even save lives. This research is still in early stages, but it brings hope for better care and safer pregnancies in the future.

SOURCE: Science Daily News, July 2025

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Bipolar Disorder !

 New Blood Test Helps Diagnose Bipolar Disorder

Researchers from the University of Cambridge have discovered a new method to help diagnose bipolar disorder using a combination of an online mental health assessment and a blood test. Many patients with bipolar disorder are misdiagnosed with major depressive disorder, as both conditions can look similar during depressive episodes. However, treatments for the two are very different, and giving the wrong medication to someone with bipolar disorder can make their symptoms worse. In this study, over 3,000 people participated by completing an online questionnaire with more than 600 questions about mood, anxiety, family history, and other psychiatric symptoms. Around 1,000 of them also sent a small blood sample using a simple finger-prick test. Researchers analyzed the blood samples and identified specific biomarkers linked to bipolar disorder. These included markers related to inflammation (e.g., IL-6), oxidative stress (e.g., 8-OHdG), and neuroplasticity (e.g., BDNF - brain-derived neurotrophic factor). These biomarkers were especially associated with manic symptoms—periods of unusually high energy, mood, or activity. The blood test alone could correctly identify about 30% of bipolar cases. When combined with the digital mental health assessment, the accuracy improved significantly. This approach could reduce the delay in correct diagnosis, which often takes years and harms patients' mental well-being. Some patients appreciated the test because it offered a biological explanation for their condition, helping reduce stigma. Researchers believe this method could soon support clinical diagnoses and lead to more personalized treatments. The findings were published in JAMA Psychiatry and mark a significant step toward using biological tools alongside traditional assessments to improve the diagnosis and care of mood disorders like bipolar disorder.

SOURCE: Science Daily News, July 2025

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Products of SQUARE Pharmaceuticals PLC.

  Product Glympa TM
  Generic Name Empagliflozin & Linagliptin
  Strength 10/ 5 mg & 25/5 mg
  Dosage form Tablet
  Therapeutic Category Oral Antidiabetic Preparation
  Product Fliban TM  
Generic Name Flibanserin
Strength 100 mg
Dosage form Tablet
Therapeutic Category Sexual Dysfunction
  Product Sopilax TM
  Generic Name Sodium Picosulfate
Strength 10 mg
  Dosage form Tablet & Oral Solution
  Therapeutic Category Laxative

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